Differential expression of steroid sulphatase locus on active and inactive human X chromosome

@article{Migeon1982DifferentialEO,
  title={Differential expression of steroid sulphatase locus on active and inactive human X chromosome},
  author={Barbara Ruben Migeon and Larry J. Shapiro and Robert A. Norum and Thuluvancheri Mohandas and Joyce Axelman and Rebecca L. Dabora},
  journal={Nature},
  year={1982},
  volume={299},
  pages={838-840}
}
The X chromosome in mammalian somatic cells is subject to unique regulation—usually genes on a single X chromosome are expressed while those on other X chromosomes are inactivated1. The X-locus for steroid sulphatase (STS; EC 3.1.6.2), the microsomal enzyme that catalyses the hydrolysis of various 3β-hydroxysteroid sulphates, is exceptional because it seems to escape inactivation. Evidence for this comes from fibroblast clones in females heterozygous for mutations that result in a severe… CONTINUE READING

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