Differential expression of sodium channel genes in retinal ganglion cells.

  title={Differential expression of sodium channel genes in retinal ganglion cells.},
  author={J Fjell and Sulayman D. Dib-Hajj and Kaj Fried and J Andrew Black and Stephen G. Waxman},
  journal={Brain research. Molecular brain research},
  volume={50 1-2},
Action potential electrogenesis in the axons of retinal ganglion cells is supported by voltage-gated sodium channels, and a tetrodotoxin (TTX)-inhibitable sodium conductance participates in anoxic injury of these axons within the optic nerve. However, the subtypes of sodium channels expressed in retinal ganglion cells have not been identified. In this study, we used reverse transcription-polymerase chain reaction (RT-PCR) and restriction enzyme mapping, together with in situ hybridization, to… CONTINUE READING
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