Differential expression of sirtuins in the aging rat brain

@inproceedings{Braidy2015DifferentialEO,
  title={Differential expression of sirtuins in the aging rat brain},
  author={Nady Braidy and Anne Poljak and Ross Grant and Tharusha Jayasena and Hussein Mansour and Tailoi Chan-Ling and George Smythe and Perminder S. Sachdev and Gilles J Guillemin},
  booktitle={Front. Cell. Neurosci.},
  year={2015}
}
Although there are seven mammalian sirtuins (SIRT1-7), little is known about their expression in the aging brain. To characterize the change(s) in mRNA and protein expression of SIRT1-7 and their associated proteins in the brain of "physiologically" aged Wistar rats. We tested mRNA and protein expression levels of rat SIRT1-7, and the levels of associated proteins in the brain using RT-PCR and western blotting. Our data shows that SIRT1 expression increases with age, concurrently with increased… CONTINUE READING
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Age related changes in NAD + metabolism , oxidative stress and Sirt 1 Activity in Wistar Rats

  • N. Braidy, G. M. H. Guillemin, T. Chan-Ling, A. Poljak, R. Grant
  • PLoS ONE
  • 2011
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