Differential expression of silent polyketide biosynthesis gene clusters in chemostat cultures of Aspergillus nidulans.

Abstract

The genome of the fungal model organism Aspergillus nidulans harbors nearly 30 polyketide synthase genes, yet the majority of these genes remain silent in the absence of particular stimuli. In this study, environmental conditions such as low specific microbial growth rate as well as nitrate, orthophosphate and glucose limitations were simulated under a… (More)
DOI: 10.1016/j.jbiotec.2012.01.015

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