Differential expression of prolactin receptor (PRLR) in normal and tumorous adrenal tissues: separation of cellular endocrine compartments by laser capture microdissection (LCM).

@article{Glasow1998DifferentialEO,
  title={Differential expression of prolactin receptor (PRLR) in normal and tumorous adrenal tissues: separation of cellular endocrine compartments by laser capture microdissection (LCM).},
  author={A. von Glasow and A Haidan and J. F. Gillespie and Paul A. T. Kelly and George P. Chrousos and Stefan R. Bornstein},
  journal={Endocrine research},
  year={1998},
  volume={24 3-4},
  pages={857-62}
}
PRL stimulates adrenal steroidogenesis. In this study, we compared the PRLR expression in normal and tumorous adrenal tissues and investigated a potential proliferative effect of PRL in adrenal cells. mRNA expression of long and intermediate forms of PRLR was detected in both normal adrenal cortex as well as benign and malignant adrenal tumors and in the human adrenocortical carcinoma cell line NCI-H295. Molecular analysis of cells procured by LCM clearly demonstrated that PRLR mRNA is… CONTINUE READING

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