Differential expression of oxidized/native lipoprotein(a) and plasminogen in human carotid and cerebral artery plaques.

@article{Umahara2011DifferentialEO,
  title={Differential expression of oxidized/native lipoprotein(a) and plasminogen in human carotid and cerebral artery plaques.},
  author={Takahiko Umahara and Toshiki Uchihara and Shingo Yamada and T. Hashimoto and Jiro Akimoto and Jo Haraoka and Toshihiko Iwamoto},
  journal={Atherosclerosis},
  year={2011},
  volume={215 2},
  pages={
          392-8
        }
}
OBJECTIVE Lipoprotein(a) [Lp(a)] is a risk factor for stroke, as has recently been further confirmed by meta analysis, and consists of low-density lipoprotein and apolipoprotein(a), which shares a significant amino acid homology with plasminogen. Oxidized Lp(a) [Ox-Lp(a)] is a more pathogenic species of Lp(a). A monoclonal antibody, specific to Ox-Lp(a), distinguishes immunolocalization of Ox-Lp(a) from that of Lp(a) and that of plasminogen which carries highly homologous domains. It is worth… CONTINUE READING
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