Differential expression of oestrogen receptors in human secondary lymphoid tissues.

  title={Differential expression of oestrogen receptors in human secondary lymphoid tissues.},
  author={Gil-Jin Shim and Delia Gherman and Hyun-Jin Kim and Yoko Omoto and Hirotaka Iwase and Didier Bouton and Lor{\'a}nd Levente Kis and Christina Thulin Andersson and Margaret Warner and Jan-{\AA}ke Gustafsson},
  journal={The Journal of pathology},
  volume={208 3},
Many autoimmune diseases including rheumatoid arthritis (RA), Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE) occur much more frequently in women than in men. There is much evidence that oestrogen is the major cause of this gender difference. Interestingly, oestrogen relieves the symptoms of RA and SS but it exacerbates SLE. This contradictory effect of oestrogen on autoimmune diseases is not well understood. Most of the effects of oestrogen are mediated by two receptors… CONTINUE READING


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