Differential expression of nucleostemin, a stem cell marker, and its variants in different types of brain tumors.

@article{Malakootian2010DifferentialEO,
  title={Differential expression of nucleostemin, a stem cell marker, and its variants in different types of brain tumors.},
  author={Mahshid Malakootian and Seyed Javad Mowla and Hooshang Saberi and Malek H Asadi and Yaser Atlasi and Afsaneh Malekzadeh Shafaroudi},
  journal={Molecular carcinogenesis},
  year={2010},
  volume={49 9},
  pages={
          818-25
        }
}
Nucleostemin (NS) is implicated in the control of stem and cancer cell proliferation. In the present study, we have examined the expression of NS and its spliced variants in various brain tumors. Total RNA was extracted from 59 brain tumor samples, and the expression of different NS spliced variants was measured by semi-quantitative RT-PCR. The subcellular distribution of NS protein in brain tumors was further examined by immunohistochemistry. Furthermore, to decipher the potential involvement… CONTINUE READING
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