Differential expression of nuclear 11beta-hydroxysteroid dehydrogenase type 2 in mineralocorticoid receptor positive and negative tissues.

@article{Petrelli1997DifferentialEO,
  title={Differential expression of nuclear 11beta-hydroxysteroid dehydrogenase type 2 in mineralocorticoid receptor positive and negative tissues.},
  author={Massimiliano Donato Petrelli and Sylvia S Lim-Tio and Jennifer Condon and Martin Hewison and P. M. Stewart},
  journal={Endocrinology},
  year={1997},
  volume={138 7},
  pages={3077-80}
}
Corticosteroid hormone action is controlled at a pre-receptor level by the activity of two isoforms of 11beta-hydroxysteroid dehydrogenase (11beta-HSD), catalyzing the interconversion of hormonally active cortisol to inactive cortisone. In particular 11beta-HSD2 protects the mineralocorticoid receptor (MR) from glucocorticoid excess, enabling aldosterone to interact with the MR. We have analyzed the subcellular localization of 11beta-HSD2 in relation to the expression of the MR in human colon… CONTINUE READING