Differential expression of novel tyrosine kinase substrates during breast cancer development.

@article{Chen2007DifferentialEO,
  title={Differential expression of novel tyrosine kinase substrates during breast cancer development.},
  author={Yunhao Chen and L T Choong and Qingsong Lin and Robin J. Philp and C Wong and Boon-Keong Ang and Yee-Ling Tan and Marie-Chiew-Shia Loh and Choy-leong Hew and Nilesh Shah and Brian J. Druker and Poh Kuan Chong and Yoon Pin Lim},
  journal={Molecular & cellular proteomics : MCP},
  year={2007},
  volume={6 12},
  pages={2072-87}
}
To identify novel tyrosine kinase substrates that have never been implicated in cancer, we studied the phosphoproteomic changes in the MCF10AT model of breast cancer progression using a combination of phosphotyrosyl affinity enrichment, iTRAQ technology, and LC-MS/MS. Using complementary MALDI- and ESI-based mass spectrometry, 57 unique proteins comprising tyrosine kinases, phosphatases, and other signaling proteins were detected to undergo differential phosphorylation during disease… CONTINUE READING

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Progressive loss of EGFR in a sub-population of breast cancers—implications in target-directed therapeutics

  • L. Y. Choong, S. Lim, +14 authors Y. P. Lim
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