Differential expression of nicotinic acetylcholine receptor genes in innervated and denervated chicken muscle.

@article{Moss1987DifferentialEO,
  title={Differential expression of nicotinic acetylcholine receptor genes in innervated and denervated chicken muscle.},
  author={Stephen J. Moss and D M Beeson and John F. Jackson and Mark G. Darlison and Eric A. Barnard},
  journal={The EMBO journal},
  year={1987},
  volume={6 13},
  pages={3917-21}
}
We have studied the mRNAs encoding all four subunits of the acetylcholine receptor in 13-day embryonic, innervated and denervated chicken pectoral muscle. In all three states the transcript sizes of the alpha, beta-, gamma- and delta-subunit mRNAs were approximately 3.2, 2.8, 1.8 and 1.9 kb respectively. Denervation was found to result in a large increase in the steady-state levels of each mRNA compared with those in innervated muscle. This increase was 8- to 9-fold for the beta and delta… CONTINUE READING

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