Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness.

@article{Benedetti1993DifferentialEO,
  title={Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness.},
  author={Maura Benedetti and Andrea Levi and Moses V Chao},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 16},
  pages={7859-63}
}
The low-affinity p75 neurotrophin receptor is believed to participate with the Trk receptor tyrosine kinase in the formation of high-affinity binding sites for nerve growth factor (NGF). To investigate the functional significance of the two NGF receptors, a truncated p75 receptor was stably expressed in PC12 rat pheochromocytoma cells, yielding cells with greatly reduced levels of wild-type p75 and normal Trk levels. Although these cells were capable of normal differentiation by NGF, very few… CONTINUE READING

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NF-kappa B signaling promotes both cell survival and neurite process formation in nerve growth factor-stimulated PC12 cells.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2000
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