Differential expression of microRNAs in mouse liver under aberrant energy metabolic status.

@article{Li2009DifferentialEO,
  title={Differential expression of microRNAs in mouse liver under aberrant energy metabolic status.},
  author={Shengjie Li and Xi Chen and Hongjie Zhang and Xiangying Liang and Yang Xiang and Chaohui Yu and Ke Zen and Youming Li and Chen-Yu Zhang},
  journal={Journal of lipid research},
  year={2009},
  volume={50 9},
  pages={1756-65}
}
Despite years of effort, exact pathogenesis of nonalcoholic fatty liver disease (NAFLD) remains obscure. To gain an insight into the regulatory roles of microRNAs (miRNAs) in aberrant energy metabolic status and pathogenesis of NAFLD, we analyzed the expression of miRNAs in livers of ob/ob mice, streptozotocin (STZ)-induced type 1 diabetic mice, and normal C57BL/6 mice by miRNA microarray. Compared with normal C57BL/6 mice, ob/ob mice showed upregulation of eight miRNAs and downregulation of… CONTINUE READING

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