Differential expression of miRNAs in papillary thyroid carcinoma compared to multinodular goiter using formalin fixed paraffin embedded tissues.

@article{Tetzlaff2007DifferentialEO,
  title={Differential expression of miRNAs in papillary thyroid carcinoma compared to multinodular goiter using formalin fixed paraffin embedded tissues.},
  author={Michael T Tetzlaff and Aihua Liu and Xiaowei Xu and Stephen R. Master and Don A. Baldwin and John W Tobias and Virginia A. Livolsi and Zubair W Baloch},
  journal={Endocrine pathology},
  year={2007},
  volume={18 3},
  pages={163-73}
}
microRNAs (miRNAs) are approximately 22 nt RNAs that negatively regulate target gene expression. Their dysregulation has been implicated in the pathogenesis of a number of human cancers, including papillary thyroid carcinoma (PTC). Whereas previous studies using microarray technologies have largely relied on the ability to procure fresh tissue at the time of surgery to characterize miRNA signatures in PTC, we exploited the ability to procure sufficient miRNA from formalin-fixed paraffin… CONTINUE READING

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