Differential expression of matrix metalloproteinase-1 in vitro corresponds to tissue morphogenesis and quality assurance of cultured skin substitutes.

@article{Swope2005DifferentialEO,
  title={Differential expression of matrix metalloproteinase-1 in vitro corresponds to tissue morphogenesis and quality assurance of cultured skin substitutes.},
  author={Viki B. Swope and Steven T Boyce},
  journal={The Journal of surgical research},
  year={2005},
  volume={128 1},
  pages={79-86}
}
OBJECTIVE To determine if matrix metalloproteinase-1 (MMP-1) was involved in the premature degradation of the dermal component in cultured skin substitutes (CSS) prepared with cells from burn patients. METHODS AND RESULTS CSS 645 and 647 were prepared from clinical human fibroblasts (HF) and keratinocytes (HK) that demonstrated premature degradation of collagen-glycosaminoglycan sponges in vitro. The control CSS were prepared from clinical HF and HK, CSS 648, and a pre-clinical cell strain… CONTINUE READING
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The effects of cross-linking of collagen-glycosaminoglycan scaffolds of compressive stiffness, chondrocyte-mediated contraction, proliferation and biosynthesis

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