Differential expression of matrilysin and cyclooxygenase-2 in intestinal and colorectal neoplasms.

@article{ShattuckBrandt1999DifferentialEO,
  title={Differential expression of matrilysin and cyclooxygenase-2 in intestinal and colorectal neoplasms.},
  author={R L Shattuck-Brandt and Laura W. Lamps and Kathleen Heppner Goss and Raymond N. Dubois and Lynn M Matrisian},
  journal={Molecular carcinogenesis},
  year={1999},
  volume={24 3},
  pages={177-87}
}
Both the matrix metalloproteinase matrilysin and the prostaglandin H synthase cyclooxygenase-2 (Cox-2), are thought to play key roles in colorectal carcinogenesis. These enzymes are overexpressed in 85-90% of human colorectal cancers. Furthermore, mice carrying an adenomatous polyposis coli germline mutation that are also nullizygous for either matrilysin or Cox-2 display a significant reduction in tumor multiplicity. To determine if there is a direct link between matrilysin and Cox-2, their… CONTINUE READING