Differential expression of intracellular acidosis in rat brainstem regions in response to hypercapnic ventilation.


We determined the regional intracellular pH (pHi) of rat brainstem in response to hypercapnia. Neutral red spectrophotometry was used to characterize changes in intracellular pH along the dorsal and ventral aspects of the medulla oblongata. Male Wistar rats (250-350 g) were infused with 3 ml of 2% Neutral Red over the course of 30 minutes. After 20 minutes… (More)


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