Differential expression of interferon-γ and chemokine genes distinguishes Rasmussen encephalitis from cortical dysplasia and provides evidence for an early Th1 immune response

@inproceedings{Owens2013DifferentialEO,
  title={Differential expression of interferon-γ and chemokine genes distinguishes Rasmussen encephalitis from cortical dysplasia and provides evidence for an early Th1 immune response},
  author={Geoffrey C. Owens and My N. Huynh and Julia W. Chang and D L Mcarthur and Michelle J. Hickey and H V Vinters and Gary W. Mathern and Carol A. Kruse},
  booktitle={Journal of Neuroinflammation},
  year={2013}
}
Rasmussen encephalitis (RE) is a rare complex inflammatory disease, primarily seen in young children, that is characterized by severe partial seizures and brain atrophy. Surgery is currently the only effective treatment option. To identify genes specifically associated with the immunopathology in RE, RNA transcripts of genes involved in inflammation and autoimmunity were measured in brain tissue from RE surgeries and compared with those in surgical specimens of cortical dysplasia (CD), a major… CONTINUE READING
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Interferon-γ , CXCL5 , CXCL9 and CXCL10 mRNA levels negatively correlated with time from seizure onset to surgery ( P < 0.05 ) , whereas CCL23 and Fas ligand transcript levels positively correlated with the degree of tissue destruction and inflammation , respectively ( P < 0.05 ) , as determined from magnetic resonance imaging ( MRI ) T2 and FLAIR images .
Rasmussen encephalitis ( RE ) is a rare complex inflammatory disease , primarily seen in young children , that is characterized by severe partial seizures and brain atrophy .
Rasmussen encephalitis ( RE ) is a rare complex inflammatory disease , primarily seen in young children , that is characterized by severe partial seizures and brain atrophy .
Interferon-γ , CXCL5 , CXCL9 and CXCL10 mRNA levels negatively correlated with time from seizure onset to surgery ( P < 0.05 ) , whereas CCL23 and Fas ligand transcript levels positively correlated with the degree of tissue destruction and inflammation , respectively ( P < 0.05 ) , as determined from magnetic resonance imaging ( MRI ) T2 and FLAIR images .
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