Differential expression of insulin-like growth factor binding protein-5 in pancreatic adenocarcinomas: identification using DNA microarray.

@article{Johnson2006DifferentialEO,
  title={Differential expression of insulin-like growth factor binding protein-5 in pancreatic adenocarcinomas: identification using DNA microarray.},
  author={Sarah K Johnson and Richard A Dennis and Gary W. Barone and Laura W. Lamps and Randy S. Haun},
  journal={Molecular carcinogenesis},
  year={2006},
  volume={45 11},
  pages={814-27}
}
Pancreatic ductal adenocarcinoma (PDAC) is characterized by its aggressiveness and resistance to both radiation and chemotherapeutic treatment. To better understand the molecular pathogenesis of pancreatic cancer, DNA array technology was employed to identify genes differentially expressed in pancreatic tumors when compared to non-malignant pancreatic tissues. RNA isolated from 11 PDACs and 14 non-malignant bulk pancreatic duct specimens was used to probe Affymetrix U95A DNA arrays. Genes that… CONTINUE READING

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