Differential expression of imprinted genes in normal and IUGR human placentas.

@article{Diplas2009DifferentialEO,
  title={Differential expression of imprinted genes in normal and IUGR human placentas.},
  author={Andreas I. Diplas and Luca Lambertini and M T Lee and Rhoda Sperling and Yin Leng Lee and James O. Wetmur and Jia Jie Chen},
  journal={Epigenetics},
  year={2009},
  volume={4 4},
  pages={235-40}
}
Genomic imprinting refers to silencing of one parental allele in the zygotes of gametes depending upon the parent of origin. Loss of imprinting (LOI) is the gain of function from the silent allele that can have a maximum effect of doubling the gene dosage. LOI may play a significant role in the etiology of intrauterine growth restriction (IUGR). Using placental tissue from ten normal and seven IUGR pregnancies, we conducted a systematic survey of the expression of a panel of 74 "putatively… CONTINUE READING

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