Differential expression of human COMT alleles in brain and lymphoblasts detected by RT-coupled 5′ nuclease assay

@article{Zhu2004DifferentialEO,
  title={Differential expression of human COMT alleles in brain and lymphoblasts detected by RT-coupled 5′ nuclease assay},
  author={Guanshan Zhu and Robert Lipsky and Ke Xu and Sameer Ali and T. Hyde and J. Kleinman and L. Akhtar and D. Mash and D. Goldman},
  journal={Psychopharmacology},
  year={2004},
  volume={177},
  pages={178-184}
}
RationaleA common polymorphism, Val158Met, alters catechol-O-methyltransferase (COMT) enzyme activity and has been linked to psychiatric phenotypes. Bray et al. (2003) reported that COMT is subject to differential allele expression in brain, finding modest (13–22%) underexpression of a haplotype containing Val158. However, disparate findings by another group who used the same method, but in lymphoblasts, raise the issues of tissue specificity, magnitude of differential expression, and identity… Expand
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