Differential expression of glutathione reductase and cytosolic glutathione peroxidase, GPX1, in developing rat lungs and kidneys.

@article{Fujii2002DifferentialEO,
  title={Differential expression of glutathione reductase and cytosolic glutathione peroxidase, GPX1, in developing rat lungs and kidneys.},
  author={Tsuneko Fujii and Takeshi Endo and Junichi Fujii and Naoyuki Taniguchi},
  journal={Free radical research},
  year={2002},
  volume={36 10},
  pages={
          1041-9
        }
}
A mutant rat GPX1 (a cytosolic predominant form), in which the selenocysteine residue in the catalytic center was replaced by cysteine, was prepared and an antibody against the mutant enzyme was raised. The resultant antibody specifically reacted with rat GPX1 and was, together with the Glutathione reductase (GR) antibody, used in a Western blot analysis and immunohistochemistry experiments. To elucidate the physiological coupling of these enzymes under oxidative stress which accompanies the… CONTINUE READING
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