Differential expression of glutamate and GABA-A receptor subunit mRNA in cortical dysplasia.

@article{Crino2001DifferentialEO,
  title={Differential expression of glutamate and GABA-A receptor subunit mRNA in cortical dysplasia.},
  author={Peter B. Crino and Ann Christine Duhaime and Gordon Baltuch and Robin White},
  journal={Neurology},
  year={2001},
  volume={56 7},
  pages={906-13}
}
OBJECTIVE Focal cortical dysplasia is characterized by disorganized cortical lamination, dysplastic and heterotopic neurons, and an association with epilepsy. The contribution that dysplastic and heterotopic neurons make to epileptogenesis in focal cortical dysplasia is unknown and the phenotype of these cells may be distinct. The authors hypothesized that the expression of genes encoding glutamatergic (glutamate [GluR] and N-methyl-D-aspartate NMDA receptors [NR]) and gamma-aminobutyric acid A… CONTINUE READING