Differential expression of glucocorticoid receptor transcripts in major depressive disorder is not epigenetically programmed.

@article{Alt2010DifferentialEO,
  title={Differential expression of glucocorticoid receptor transcripts in major depressive disorder is not epigenetically programmed.},
  author={Simone R Alt and Jonathan D Turner and Melanie D. Klok and Onno C. Meijer and E A J F Egbert A J F Lakke and Roel H Derijk and Claude P. Muller},
  journal={Psychoneuroendocrinology},
  year={2010},
  volume={35 4},
  pages={544-56}
}
Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis is one of the most consistent findings in major depressive disorder (MDD). Impaired HPA feedback may be due to the lower glucocorticoid receptor (GR) or mineralocorticoid receptor (MR) levels in the forebrain. GR levels are transcriptionally controlled by multiple untranslated alternative first exons, each with its own promoter providing a mechanism for tissue-specific fine-tuning of GR levels. Recently epigenetic methylation of… CONTINUE READING
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