Differential expression of exon 5 splice variants of sodium channel alpha subunit mRNAs in the developing mouse brain.

@article{Gazina2010DifferentialEO,
  title={Differential expression of exon 5 splice variants of sodium channel alpha subunit mRNAs in the developing mouse brain.},
  author={Elena V. Gazina and Kay L. Richards and Makhfudzah Mokhtar and Evan A. Thomas and Christopher A. Reid and Steven Petrou},
  journal={Neuroscience},
  year={2010},
  volume={166 1},
  pages={195-200}
}
Sodium channel alpha subunit genes expressed in the human brain, SCN1A, SCN2A, SCN3A and SCN8A, are subject to alternative splicing of coding exons 5N and 5A. In this study we examined expression of alpha subunit mRNA and exon 5 splicing in the developing mouse brain. Expression levels of Scn1a, Scn2a and Scn8a mRNAs increase postnatally, whereas Scn3a mRNA expression levels decrease. Scn1a mRNA contains only exon 5A, due to the absence of exon 5N in the mouse Scn1a gene. At birth, Scn2a is the… CONTINUE READING

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