Differential expression of epithelial–mesenchymal transition and stem cell markers in intrinsic subtypes of breast cancer

@article{Pomp2015DifferentialEO,
  title={Differential expression of epithelial–mesenchymal transition and stem cell markers in intrinsic subtypes of breast cancer},
  author={Victoria Pomp and Cornelia Leo and Andrea A Mauracher and Dimitri Korol and Wenjun Guo and Zsuzsanna Varga},
  journal={Breast Cancer Research and Treatment},
  year={2015},
  volume={154},
  pages={45-55}
}
The transcription factors SLUG and SOX9 have been shown to define mammary stem cell state. Similarly, epithelial–mesenchymal transition (EMT) markers (E-Cadherin, mTOR) have been shown to play a role in tumor-progression and metastatic potential in breast cancer. Finally, SOX10 is known to be expressed in breast cancer as well. The overexpressions of EMT and stem cell markers have been shown to correlate with poor overall survival. In this study, we examined whether the expression of these… CONTINUE READING
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