Differential expression of efflux pump genes of Mycobacterium tuberculosis in response to varied subinhibitory concentrations of antituberculosis agents.

@article{Garima2015DifferentialEO,
  title={Differential expression of efflux pump genes of Mycobacterium tuberculosis in response to varied subinhibitory concentrations of antituberculosis agents.},
  author={Kushal Garima and Rakesh M. Pathak and Rashmi Tandon and Nisha Rathor and Rajesh Sinha and Mridula Bose and Mandira Varma-Basil},
  journal={Tuberculosis},
  year={2015},
  volume={95 2},
  pages={
          155-61
        }
}
Several reports have elaborated on the role of efflux pumps in drug resistance in Mycobacterium tuberculosis by analysing the mRNA expression profiles. However, there is no uniformity in the subinhibitory concentrations of drugs chosen in these studies. Some investigators studied the expression of efflux pumps under a drug concentration of 1/2 minimum inhibitory concentration (MIC), while others used 1/3, 1/4 or 1/8MIC. The present study was planned to understand the effect of different… CONTINUE READING
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