Differential expression of collagen types I, II, III, and X in human osteophytes.

  title={Differential expression of collagen types I, II, III, and X in human osteophytes.},
  author={Thomas Aigner and Uwe Dietz and Helmut St{\"o}ss and Klaus von der Mark},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  volume={73 2},
BACKGROUND Osteophytes are neoplastic cartilaginous and osseous protrusions growing at the margins of osteoarthritic joints. Their formation involves complex patterns of cellular proliferation, differentiation, as well as matrix synthesis and turnover that are poorly understood. EXPERIMENTAL DESIGN Here we report on an experimental approach using in situ hybridization and immunohistology to elucidate pathways of chrondrocyte differentiation in human osteophytes. Ab and cDNA probes for… CONTINUE READING
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