Differential expression of claudin-2 in normal human tissues and gastrointestinal carcinomas

@article{Aung2005DifferentialEO,
  title={Differential expression of claudin-2 in normal human tissues and gastrointestinal carcinomas},
  author={Phyu P Aung and Yoshitsugu Mitani and Yuichi Sanada and Hirofumi Nakayama and Keisuke Matsusaki and Wataru Yasui},
  journal={Virchows Archiv},
  year={2005},
  volume={448},
  pages={428-434}
}
Claudins are involved in the formation of tight junctions in epithelial and endothelial cells. Claudins form a family of 24 members displaying organ- and tissue-specific patterns of expression. In the present study, we evaluated the specificity of the claudin-2 expression in various normal human tissues and gastrointestinal cancers by quantitative reverse transcriptase–polymerase chain reaction and immunohistochemistry. In 14 various normal tissues, claudin-2 mRNA was expressed in the kidney… CONTINUE READING