Differential expression of chemokine receptors on uveal melanoma cells and their metastases.

@article{Li2008DifferentialEO,
  title={Differential expression of chemokine receptors on uveal melanoma cells and their metastases.},
  author={Haochuan Li and Hassan Alizadeh and Jerry Y. Niederkorn},
  journal={Investigative ophthalmology \& visual science},
  year={2008},
  volume={49 2},
  pages={
          636-43
        }
}
PURPOSE To determine the expression of the chemokine receptors CXCR4 and CCR7 on human uveal melanoma cells and their metastases and the effect of liver-borne factors on the chemotactic responses of uveal melanoma cells. METHODS Four human uveal melanoma cell lines and three cell lines of uveal melanoma metastases were examined by RT-PCR and flow cytometry for their constitutive expression of CXCR4 and CCR7. The effect of the liver and liver-borne factors on the expression of CXCR4 and CCR7… 
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Inhibition of chemokine receptor expression on uveal melanomas by CXCR4 siRNA and its effect on uveal melanoma liver metastases.

CXCR4 is a key chemokine receptor that may account for the organ-specific homing of human uveal melanomas to the liver, which contains significant quantities of CXCL2, the only known ligand for CX CR4.

Epigenetic regulation of CXCR4 expression by the ocular microenvironment.

It is demonstrated that ocular microenvironment factors induce methylation and downregulation of tumor CXCR4 expression through methyltransferase and histone deacetylase activities.

Chemokine receptor CCR7 expression predicts poor outcome in uveal melanoma and relates to liver metastasis whereas expression of CXCR4 is not of clinical relevance.

The data suggest that CCR7 plays a role in uveal melanoma metastasis and is associated with poor survival and may prove to be a target for therapeutic intervention.

PD-L1: PD-1 interaction contributes to the functional suppression of T-cell responses to human uveal melanoma cells in vitro.

The results imply that the presence of IFN-gamma in the tumor local microenvironment promotes upregulation of PD-L1 expression by uveal melanoma, which may, in part, promote immune escape by impairing T-cell function.

Molecular profiling of primary uveal melanomas with tumor-infiltrating lymphocytes

Molecular profiling of uveal melanoma tumors with TILs supports the existence of an immunosuppressive tumor microenvironment and suggests roles for CD8+ regulatory T cells, as well as specific chemokines, in fostering uvea melanoma disease progression.

Natural killer cells and pigment epithelial-derived factor control the infiltrative and nodular growth of hepatic metastases in an Orthotopic murine model of ocular melanoma

A role for NK cells is demonstrated in the development of the infiltrative growth pattern, and a role for PEDF in theDevelopment of the nodular pattern is demonstrated.

Expression of haematogenous and lymphogenous chemokine receptors and their ligands on uveal melanoma in association with liver metastasis

Examination of the expression of the chemokine receptors CXCR4, CCR7 and CCR10 as well as their respective Chemokine ligands in human uveal melanomas found them to be activators of cancer cell distribution and target organs.

CXCR 4 and Cancer

Observations reveal that CXCR4 is an important molecule involved in several aspects of cancer progression and how dysregulation contributes to disease progression, and is one of the most studied chemokine receptors.

C-C Chemokine Receptor 7 in Cancer

The data indicated that in different cancers, CCR7 plays distinct roles in directing cells to lymph nodes, the skin or to the central nervous system, and in certain tumors, it may even serve a protective role.

Overexpression of the chemokine receptors CXCR4, CCR7, CCR9, and CCR10 in human primary cutaneous melanoma: a potential prognostic value for CCR7 and CCR10?

Two chemokine receptors permitting the identification of high-risk patients were identified: CCR7 and CCR10 overexpressions were found to be associated with a worse outcome of disease course independent of Breslow’s tumor thickness and Clark level, thus representing possible additional prognostic markers.

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  • A. Zlotnik
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    International journal of cancer
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These studies point to the following conclusions: (i) Tumors express chemokine receptors in a nonrandom manner, and CXCR4 is the most widely expressed chemokines and receptors in many different cancers.
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