Differential expression of chemokine receptors on uveal melanoma cells and their metastases.

  title={Differential expression of chemokine receptors on uveal melanoma cells and their metastases.},
  author={Haochuan Li and Hassan Alizadeh and Jerry Y. Niederkorn},
  journal={Investigative ophthalmology \& visual science},
  volume={49 2},
PURPOSE To determine the expression of the chemokine receptors CXCR4 and CCR7 on human uveal melanoma cells and their metastases and the effect of liver-borne factors on the chemotactic responses of uveal melanoma cells. METHODS Four human uveal melanoma cell lines and three cell lines of uveal melanoma metastases were examined by RT-PCR and flow cytometry for their constitutive expression of CXCR4 and CCR7. The effect of the liver and liver-borne factors on the expression of CXCR4 and CCR7… 

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