Differential expression of cell adhesion molecules by human hematopoietic progenitor cells from bone marrow and mobilized adult peripheral blood

@article{Turner1995DifferentialEO,
  title={Differential expression of cell adhesion molecules by human hematopoietic progenitor cells from bone marrow and mobilized adult peripheral blood},
  author={Marc Turner and R. S. Anthony and Alistair C. Parker and Kathleen Mcilwaine},
  journal={STEM CELLS},
  year={1995},
  volume={13}
}
The mechanisms responsible for mobilization of hematopoietic progenitor cells (HPC) from the bone marrow into the circulation are unknown. One possibility is that HPC downregulate cell adhesion molecule expression. We studied normal human bone marrow and adult peripheral blood following 4g/m2 cyclophosphamide and recombinant human granulocyte colony‐stimulating factor (rHuG‐CSF). Each sample was studied for the coexpression of CD34 and a panel of cell adhesion molecules by dual immunocytometry… Expand
Difference between Expression of Adhesion Molecules on CD34+ Cells from Bone Marrow and G‐CSF‐Stimulated Peripheral Blood
Three‐color immunofluorescence cytometry was used to quantify the expression of different adhesion molecules on CD34+ cells of steady‐state bone marrow (BM) and peripheral blood stem cells (PBSC)Expand
Research Report Quantitative Expression of Adhesion Molecules on Granulocyte Colony-Stimulating Factor-Mobilized Peripheral Blood, Bone Marrow, and Cord Blood CD34 1 Cells
TLDR
The quantitative expression of the main receptors on CD34 1 cells explained cellular functions during the different steps of hematopoietic stem cells transplantation. Expand
Circulating CD34+ cells in cord blood and mobilized blood have a different profile of adhesion molecules than bone marrow CD34+ cells
TLDR
The expression of adhesion molecules was studied on CD34+ hematopoietic precursors in cord blood, bone marrow and mobilized blood and found high expression of L‐selectin may facilitate interaction with endothelial cells and may favour mobilization. Expand
Quantitative expression of adhesion molecules on granulocyte colony-stimulating factor-mobilized peripheral blood, bone marrow, and cord blood CD34+ cells.
TLDR
Quantitative analysis revealed that CD18 was more strongly expressed on BM than on PB cells to promote progenitors adhesion by interacting with stromal cells, and explained cellular functions during the different steps of hematopoietic stem cells transplantation. Expand
Adhesion molecule expression by bone marrow CD34-positive cells in aplastic anemia before and after immunosuppressive therapy.
TLDR
Changes in adhesion molecule expression by stem cells are important in the pathology of aplastic anemia, and their expression was significantly decreased after hematological recovery. Expand
Different expression of adhesion molecules on myeloid and B‐lymphoid CD34+ progenitors in normal bone marrow
TLDR
It is concluded that B lymphoid and early and late myeloid CD34+ precursors in normal bone marrow show a different profile of adhesion molecules, which could reflect a higher tendency of the myeloids CD34+. Expand
CD34+ cells and CD34+CD38- subset from mobilized blood show different patterns of adhesion molecules compared to those from steady-state blood, bone marrow, and cord blood.
TLDR
The control of antigen density of these adhesion molecules is likely to be clinically important for effective mobilization of HPC as well as for rapid engraftment following HPC transplant. Expand
Different expression of adhesion molecules on CD34+ cells in AML and B‐lineage ALL and their normal bone marrow counterparts
TLDR
An aberrant expression of adhesion molecules may be used for the detection of minimal residual leukemia in patients with acute myeloid leukemia and B‐lineage acute lymphoblastic leukemia. Expand
PECAM-1 is expressed on hematopoietic stem cells throughout ontogeny and identifies a population of erythroid progenitors.
TLDR
Results demonstrate CD31 expression on hematopoietic stem cells throughout ontogeny and identify a population of CD31+ short-term erythroid progenitors cells that confer protection from lethal doses of radiation. Expand
G‐CSF‐mobilized CD34+ peripheral blood stem cells are significantly less apoptotic than unstimulated peripheral blood CD34+ cells: role of G‐CSF as survival factor
The mechanism of release of CD34+ cells into the peripheral blood (PB) after mobilization treatment with chemotherapy and/or growth factors is not clearly understood. Growth factors may induceExpand
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References

SHOWING 1-10 OF 25 REFERENCES
Expression and function of adhesion molecules on human hematopoietic stem cells: CD34+ LFA-1- cells are more primitive than CD34+ LFA-1+ cells.
TLDR
Data provide a rationale for the administration of anti- LFA-1 antibody after bone marrow transplantation for reducing the graft failure and clarify the role of adhesion molecules in HSCs. Expand
Expression of integrins and examination of their adhesive function in normal and leukemic hematopoietic cells.
TLDR
Very late antigen (VLA) integrin expression on normal CD34+ marrow progenitors, on leukemic cell lines, and on blasts from patients with acute myelogenous or monocytic leukemias is characterized. Expand
The heparin binding PECAM-1 adhesion molecule is expressed by CD34+ hematopoietic precursor cells with early myeloid and B-lymphoid cell phenotypes.
TLDR
It is shown that enriched CD34+ human hematopoietic progenitor cell populations, containing early myeloid, erythroid, and multipotential progenitors cells, are CD31+. Expand
Identification and comparison of CD34-positive cells and their subpopulations from normal peripheral blood and bone marrow using multicolor flow cytometry.
TLDR
It is shown that CD34+ cells and their subsets can be identified in normal PB and that the relative frequency of these Cells and their subpopulations differs in PB versus BM. Expand
Expression of the CD11/CD18, leukocyte adhesion molecule 1, and CD44 adhesion molecules during normal myeloid and erythroid differentiation in humans.
TLDR
Investigation of the pattern of expression of the CD11/CD18, CD44, and leukocytes adhesion molecule 1 (LAM-1) adhesion molecules during myeloid and erythroid differentiation in humans suggests that at least some of these molecules are critically involved in leukocyte adhesion during development. Expand
Expression of intercellular adhesion molecule-1 (CD54) on hematopoietic progenitors.
TLDR
Results indicate that maturation of cells of the erythroid and myeloid lineage is associated with loss of ICAM-1, and suggests that IC AM-1 may play a role in the cell-cell and cell-stromal interactions that regulate hematopoiesis. Expand
Distribution of surface-membrane molecules on bone marrow and cord blood CD34+ hematopoietic cells.
TLDR
Investigation of the distribution of membrane molecules on CD34+ hematopoietic cells isolated from human bone marrow (BM) and cord blood (CB) shows that althoughCD34+ cells from BM constitute a more heterogeneous population, resident and circulating CD34+. Expand
Hematopoietic progenitor cell expression of the H-CAM (CD44) homing-associated adhesion molecule.
TLDR
Evidence is provided that molecules related or identical to the H-CAM homing receptor are expressed on marrow progenitor cells, which may contribute to progenitors cell interactions with marrow endothelial and stromal cell elements important to the maintenance and regulation of hematopoiesis. Expand
Characterization of chemotherapy mobilized peripheral blood progenitor cells for use in autologous stem cell transplantation.
TLDR
Data indicate that CD34+ cells mobilized during recovery from chemotherapy are predominantly myeloid in phenotype and contain few actively proliferating cells or cells with lymphoid phenotypes. Expand
Expression of integrins in human bone marrow
TLDR
The regulated expression and specific localization of integrins in the bone marrow suggest that these molecules may have a role in normal haemopoiesis. Expand
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