Differential expression of apoptosis associated genes bax and bcl-2 in ovarian cancer.

@article{Marx1997DifferentialEO,
  title={Differential expression of apoptosis associated genes bax and bcl-2 in ovarian cancer.},
  author={Dagmar Marx and Claudia Binder and Harald Meden and T Lenthe and T Ziemek and T Hiddemann and Walther Christian Kuhn and Alfred Schauer},
  journal={Methods in molecular medicine},
  year={1997},
  volume={39},
  pages={687-91}
}
The prognostic value of various molecular markers, which adequately account for the tumor biology and disease behaviour of ovarian cancer, is still unclear. Recent studies have focused on the role of genes regulating the balance between proliferation and cellular suicide, apoptosis. In the present study, tumor tissue from 215 patients with ovarian cancer was immunohistochemically analysed for Bax- and Bcl-2-expression. There was an association between Bcl-2-expression (30%) and factors of… CONTINUE READING