Differential expression of matrix-metalloproteinase-1 and -2 genes in normal and fibrotic human liver.

@article{Milani1994DifferentialEO,
  title={Differential expression of matrix-metalloproteinase-1 and -2 genes in normal and fibrotic human liver.},
  author={Stefano Milani and Hermann Herbst and Detlef B Schuppan and Cecilia Grappone and Giulia Pellegrini and Massimo Pinzani and A Casini and Antonio Calabr{\`o} and G Ciancio and Federico Stefanini},
  journal={The American journal of pathology},
  year={1994},
  volume={144 3},
  pages={528-37}
}
Altered degradation of extracellular matrix has been implicated in the pathogenesis of hepatic fibrosis. We investigated levels and cellular sites of gene expression of two major collagen-degrading enzymes, matrix-metalloproteinase (MMP)-1 (fibroblast type-interstitial collagenase) and MMP-2 (72-kd gelatinase, type IV collagenase) in five normal and 18 fibrotic human livers as well as in cultured human hepatic fat-storing cells by Northern blot analysis and in situ hybridization. Fat-storing… CONTINUE READING