Differential expression of alphav integrins in K1735 melanoma cells.

  title={Differential expression of alphav integrins in K1735 melanoma cells.},
  author={Xiaowu Li and Biliang Chen and Scott D Blystone and Kevin P. Mchugh and Frederick Ross and D. Mart{\'i}nez Ramos},
  journal={Invasion & metastasis},
  volume={18 1},
Tumor cell adherence to and migration on the extracellular matrix is an important aspect of cancer progression. This interaction with the extracellular matrix is mediated primarily through the integrin class of cell adhesion molecules. We identified a restricted expression of alphavbeta3 in highly metastatic K1735M2 and of alphavbeta5 in poorly metastatic K1735C23 murine melanoma cells. The highly metastatic cells were ten times more motile on vitronectin and fibronectin and approximately three… CONTINUE READING

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