Differential expression of alpha and beta thyroid hormone receptor genes in rat brain and pituitary.

@article{Bradley1989DifferentialEO,
  title={Differential expression of alpha and beta thyroid hormone receptor genes in rat brain and pituitary.},
  author={D J Bradley and W Scott Young and Cary Weinberger},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 18},
  pages={7250-4}
}
Multiple thyroid hormone receptor cDNAs have previously been identified in rat and are classified into alpha and beta subtypes. Alternative splicing of the alpha gene gives rise to the functional receptor, rTR alpha 1, and the non-thyroid hormone-binding isotype, rTR alpha 2. Recent evidence suggests the beta gene encodes two functional receptors, rTR beta 1, and the pituitary-specific receptor, rTR beta 2. By using synthetic DNA probes common to rTR beta transcripts and specific for rTR alpha… CONTINUE READING
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