Differential expression of Toll-like receptor (TLR)-2 and TLR-4 on monocytes in human sepsis.

@article{Armstrong2004DifferentialEO,
  title={Differential expression of Toll-like receptor (TLR)-2 and TLR-4 on monocytes in human sepsis.},
  author={Lynne V Armstrong and Andrew R. L. Medford and K J Hunter and Kay M. Uppington and Ann B. Millar},
  journal={Clinical and experimental immunology},
  year={2004},
  volume={136 2},
  pages={
          312-9
        }
}
Toll-like receptors (TLRs) are a recently described family of immune receptors involved in the recognition of pathogen-associated molecular patterns (PAMPs). The central role of TLR-2 and TLR-4 in microbial responses suggests they may be implicated in the pathogenesis of human sepsis. We hypothesized that the incidence and outcome of sepsis would be influenced by the expression of TLR-2 and TLR-4 on monocytes. We have examined the expression of TLR-2 and TLR-4 mRNA and protein and their… CONTINUE READING
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