Differential expression of TRAIL and TRAIL receptors in allergic asthmatics following segmental antigen challenge: evidence for a role of TRAIL in eosinophil survival.

@article{Robertson2002DifferentialEO,
  title={Differential expression of TRAIL and TRAIL receptors in allergic asthmatics following segmental antigen challenge: evidence for a role of TRAIL in eosinophil survival.},
  author={Noreen Robertson and James G. Zangrilli and Andrzej Steplewski and Annette Hastie and Rochelle G. Lindemeyer and Maria A. Planeta and Mary Kathryn Smith and Nathalie Innocent and Ali Imran Musani and Rodolfo M Pascual and Stephen L. Peters and Gerald Litwack},
  journal={Journal of immunology},
  year={2002},
  volume={169 10},
  pages={5986-96}
}
Asthma is a chronic lung disease exhibiting airway obstruction, hyperresponsiveness, and inflammation, characterized by the infiltration of eosinophils into the airways and the underlying tissue. Prolonged eosinophilic inflammation depends on the balance between the cell's inherent tendency to undergo apoptosis and the local eosinophil-viability enhancing activity. TRAIL, a member of the TNF family, induces apoptosis in most transformed cells; however, its role in health and disease remains… CONTINUE READING
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