Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers

  title={Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers},
  author={Mar{\'i}a Salud Dom{\'i}nguez-S{\'a}nchez and Carmen S{\'a}ez and Miguel {\'A}. Jap{\'o}n and Andr{\'e}s Aguilera and Rosa Luna},
  booktitle={BMC Cancer},
One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP requires the participation of a number of conserved factors such as the THO complex. THO interacts physically and functionally with the Sub2/UAP56 RNA-dependent ATPase, and the Yra1/REF1/ALY RNA-binding protein linking transcription, mRNA export and genome integrity. Given the link between genome instability and cancer, we have performed a comparative analysis of the expression… CONTINUE READING


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