Differential expression of PDGFRB and EGFR in microvascular proliferation in glioblastoma

  title={Differential expression of PDGFRB and EGFR in microvascular proliferation in glioblastoma},
  author={Guiyan Xu and Jian Yi Li},
  journal={Tumor Biology},
Glioblastoma (GBM) is the highly malignant glioma and exhibits microvascular proliferation. PCR mRNA arrays and immunohistochemical stains on tissue microarray demonstrated that the expression level of PDGFRB in GBM microvascular proliferation was significantly higher than that in GBM tumor cells while the expression level of EGFR was lower in microvascular proliferation than in GBM tumor cells. PDGFRB protein was selectively expressed in pericytes in GBM microvascular proliferation. By… CONTINUE READING
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