Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues.

@article{Ishida2002DifferentialEO,
  title={Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues.},
  author={Masayoshi Ishida and Yoshiko Iwai and Yoshimasa Tanaka and Taku Okazaki and Gordon J Freeman and Nagahiro Minato and T. Honjo},
  journal={Immunology letters},
  year={2002},
  volume={84 1},
  pages={57-62}
}
PD-1 is a member of the immunoglobulin superfamily expressed on immune cells, including T and B cells, and is involved in the delivery of inhibitory signal upon engagement of its ligands, PD-L1 and PD-L2. While the expression profile of PD-1 has been well documented, the analysis of PD-L1 and PD-L2 distributions on a protein basis has not been carried out because of the lack of available monoclonal antibodies specific for the molecules. In this study, we established two monoclonal antibodies, 1… CONTINUE READING

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