Differential expression of Na+-Cl- cotransporter and Na+-K+-Cl- cotransporter 2 in the distal nephrons of euryhaline and seawater pufferfishes.

@article{Kato2011DifferentialEO,
  title={Differential expression of Na+-Cl- cotransporter and Na+-K+-Cl- cotransporter 2 in the distal nephrons of euryhaline and seawater pufferfishes.},
  author={Akira Kato and Takayuki Muro and Yuuri Kimura and Shanshan Li and Zinia Islam and Maho Ogoshi and Hiroyuki Doi and Shigehisa Hirose},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2011},
  volume={300 2},
  pages={R284-97}
}
The process of NaCl reabsorption in the distal nephron allows freshwater fishes to excrete hypotonic urine and seawater fishes to excrete urine containing high concentrations of divalent ions; the relevant transporters, however, have not yet been identified. In the mammalian distal nephron, NaCl absorption is mediated by Na(+)-K(+)-Cl(-) cotransporter 2 (NKCC2, Slc12a1) in the thick ascending limb, Na(+)-Cl(-) cotransporter (NCC, Slc12a3) in the distal convoluted tubule, and epithelial sodium… CONTINUE READING
Highly Cited
This paper has 293 citations. REVIEW CITATIONS
19 Citations
58 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

293 Citations

050100150'12'14'16'18
Citations per Year
Semantic Scholar estimates that this publication has 293 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 58 references

Similar Papers

Loading similar papers…