Differential expression of MHC class II molecules in highly metastatic breast cancer cells is mediated by the regulation of the CIITA transcription Implication of CIITA in tumor and metastasis development.

@article{Shi2006DifferentialEO,
  title={Differential expression of MHC class II molecules in highly metastatic breast cancer cells is mediated by the regulation of the CIITA transcription Implication of CIITA in tumor and metastasis development.},
  author={Bo Shi and Ant{\`o}nia Vinyals and Pedro Al{\'i}a and Cristina Broce{\~n}o and Feisong Chen and Marc Adrover and Carme Gelpi and Janet E. Price and {\'A}ngels Fabra},
  journal={The international journal of biochemistry & cell biology},
  year={2006},
  volume={38 4},
  pages={544-62}
}
We analyzed the differential gene expression between variants of MDA-MB-435 human breast cancer cell line that share an identical genetic background but have different metastatic ability. The major histocompatibility complex class II was found down-regulated in highly metastatic cells and correlated with MHC transactivator (CIITA) expression. Constitutive CIITA expression observed in poorly metastatic is driven by promoters III and IV of CIITA gene. Conversely, both promoters were ineffective… CONTINUE READING