Differential expression of KIT/PDGFRA mutant isoforms in epithelioid and mixed variants of gastrointestinal stromal tumors depends predominantly on the tumor site

@article{Wasg2004DifferentialEO,
  title={Differential expression of KIT/PDGFRA mutant isoforms in epithelioid and mixed variants of gastrointestinal stromal tumors depends predominantly on the tumor site},
  author={Bartosz Wasąg and Maria Debiec-Rychter and Patrick Pauwels and Michel S. Stul and Hilde Vranckx and A. van Oosterom and Anne M. Hagemeijer and Rafa{\"e}l Sciot},
  journal={Modern Pathology},
  year={2004},
  volume={17},
  pages={889-894}
}
Gastrointestinal stromal tumors (GISTs) form a distinctive group of mesenchymal neoplasms, showing differentiation towards the interstitial cells of Cajal. Morphologically, GISTs vary from cellular spindle cell tumors to epithelioid or mixed, epithelioid and spindle cell variants. The genotypic features underlying the morphologic differences of GISTs with vs without epithelioid components are not well defined. Acquisition of activating mutations in KIT and PDGFRA has been reported as… CONTINUE READING
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