Differential expression of IGFBPs by normal and hypertrophic scar fibroblasts.

@article{Hathaway1996DifferentialEO,
  title={Differential expression of IGFBPs by normal and hypertrophic scar fibroblasts.},
  author={C L Hathaway and Alice M. Arnold and R P Rand and Loren H. Engrav and Lebris S Quinn},
  journal={The Journal of surgical research},
  year={1996},
  volume={60 1},
  pages={156-62}
}
Insulin-like growth factor-I (IGF-I) is a potent fibroblast mitogen which influences wound healing. IGF action is regulated by a family of six IGF-binding proteins (IGFBPs). The purpose of this study was to determine if expression of IGFBPs is altered in hypertrophic scarring, a wound-healing condition commonly associated with deep dermal injury. Fibroblast populations from the superficial and deep dermal layers of normal human skin (SN and DN, respectively) and from superficial and deep layers… CONTINUE READING