Differential expression of HDAC3, HDAC7 and HDAC9 is associated with prognosis and survival in childhood acute lymphoblastic leukaemia.

@article{Moreno2010DifferentialEO,
  title={Differential expression of HDAC3, HDAC7 and HDAC9 is associated with prognosis and survival in childhood acute lymphoblastic leukaemia.},
  author={Daniel Antunes Moreno and Carlos Alberto Scrideli and Maria Angelica Cortez and Rosane Gomes de Paula Queiroz and Elvis Terci Valera and Vanessa da Silva Silveira and Jos{\'e} Andr{\'e}s Yunes and S{\'i}lvia Regina Brandalise and Luiz Gonzaga Tone},
  journal={British journal of haematology},
  year={2010},
  volume={150 6},
  pages={665-73}
}
Altered expression of histone deacetylases (HDACs) is a common feature in several human malignancies and may represent an interesting target for cancer treatment, including haematological malignancies. We evaluated the mRNA gene expression profile of 12 HDAC genes by quantitative real-time polymerase chain reaction in 94 consecutive childhood acute lymphoblastic leukaemia (ALL) samples and its association with clinical/biological features and survival. ALL samples showed higher expression… CONTINUE READING
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