Differential expression of GAD65 and GAD67 in human, rat, and mouse pancreatic islets.

  title={Differential expression of GAD65 and GAD67 in human, rat, and mouse pancreatic islets.},
  author={Joohyung Kim and Walter Richter and Henk Jan Aanstoot and Yan Shi and Q. K. Fu and Ray V. Rajotte and G. Warnock and Steinunn Baekkeskov},
  volume={42 12},
The smaller form of the autoantigen glutamic acid decarboxylase, GAD65 (formerly the 64,000 M(r) autoantigen), is a major target of humoral autoimmunity in type I diabetes. Human autoantisera have been used extensively to characterize the GAD65 antigen in both rat and human islets, but the protein has escaped detection in mouse islets. We have now analyzed the expression of GAD65 and GAD67, the larger glutamic acid decarboxylase protein, in human, rat, and mouse islets of Langerhans and brain… CONTINUE READING


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