Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils

@article{Liles1996DifferentialEO,
  title={Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils},
  author={W Conrad Liles and Peter A. Kiener and Jeffrey A. Ledbetter and Alejandro Aruffo and Seymour J. Klebanoff},
  journal={The Journal of Experimental Medicine},
  year={1996},
  volume={184},
  pages={429 - 440}
}
Human neutrophils, monocytes, and eosinophils are known to undergo apoptotic cell death. The Fas/Fas ligand pathway has been implicated as an important cellular pathway mediating apoptosis in diverse cell types. We conducted studies to examine the importance of the Fas/FasL system in normal human phagocytes. Although Fas expression was detected on neutrophils, monocytes, and eosinophils, constitutive expression of FasL was restricted to neutrophils. The three types of phagocytes demonstrated… CONTINUE READING
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