Differential expression of EGFR during early reparative phase of the gastric mucosa between young and aged rats.

@article{Liu1998DifferentialEO,
  title={Differential expression of EGFR during early reparative phase of the gastric mucosa between young and aged rats.},
  author={Lei Liu and Jerrold R Turner and Yingjie Yu and Ahmed J Khan and Richard Jaszewski and Suzanne E. G. Fligiel and Adhip P. N. Majumdar},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={1998},
  volume={275 5},
  pages={G943-G950}
}
Aging is associated with decreased reparative ability of the gastric mucosa. Our recent data suggest a role for epidermal growth factor receptor (EGFR) in the mucosal reparative processes. Thus we examined changes in EGFR tyrosine kinase activity as well as expression and subcellular localization of EGFR and its ligand transforming growth factor-α (TGF-α) in the gastric mucosa of young (4-mo-old) and aged (24-mo-old) Fischer 344 male rats during the early reparative phase after acute injury… CONTINUE READING
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creased expression of EGFR in gastric mucosa of aged rats

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Aging enhances gastric mucosal sensitivity to EGF and TGF-a (Abstract)

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