Differential expression of CYP3A12 and CYP3A26 mRNAs in canine liver and intestine.

@article{Mealey2008DifferentialEO,
  title={Differential expression of CYP3A12 and CYP3A26 mRNAs in canine liver and intestine.},
  author={Katrina L Mealey and Mohamed Jabbes and Elizabeth Spencer and Joshua M. Akey},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={2008},
  volume={38 10},
  pages={
          1305-12
        }
}
The cytochrome P450 (CYP) 3A family is often considered the most important CYP subfamily with regard to drug metabolism in people. Certainly, CYP3A4 contributes to poor oral bioavailability of a number of drugs, and a tremendous amount of effort has been made in attempting to find an appropriate model system to predict the oral bioavailability of candidate drugs. The dog is a species widely used as a preclinical model for the evaluation of drug safety and pharmacokinetics. Compared with other… CONTINUE READING

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