Differential expression of ATP-binding cassette and/or major facilitator superfamily class efflux pumps contributes to voriconazole resistance in Aspergillus flavus.

@article{Natesan2013DifferentialEO,
  title={Differential expression of ATP-binding cassette and/or major facilitator superfamily class efflux pumps contributes to voriconazole resistance in Aspergillus flavus.},
  author={Suganthini Krishnan Natesan and A K Lamichchane and Subramanian Poothamkurissi Swaminathan and Wenjuan Wu},
  journal={Diagnostic microbiology and infectious disease},
  year={2013},
  volume={76 4},
  pages={458-63}
}
Invasive aspergillosis remains a life-threatening infection in immunocompromised patients. Although clinical failures are attributed to poor host immunity, antifungal drug resistance may be a contributing factor. Reports of voriconazole (VRC) resistance (VRC-R) in clinical isolates of Aspergillus spp. continue to emerge from various centers around the world, and mechanisms contributing to drug resistance are poorly understood. The aim of this study is to study the role of multidrug resistance… CONTINUE READING

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